A statistical approach for analyzing data from the in vivo Pig-a gene mutation assay.

Bernd-Wolfgang Igl,Stephen D Dertinger,Vasily N Dobrovolsky,Marian Raschke,Andreas Sutter,Richardus Vonk

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2018）

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摘要

•The proposed statistical model uses both treatment and longitudinal information.•Treatment and longitudinal effects can be determined within and between groups.•Pre-treatment measurements can be used as a covariate to increase precision.•This kind of statistical analysis is quite new in preclinical settings.

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关键词

In vivo Pig-a test,Linear model,Multiple contrasts

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