Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice.

J K Dunnick,A R Pandiri,B A Merrick,G E Kissling,H Cunny, E Mutlu,S Waidyanatha,R Sills,H L Hong, T V Ton,T Maynor,L Recio,S L Phillips,M J Devito,A Brix

Toxicology Reports（2018）

引用 33|浏览23

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摘要

•Pentabrominated diphenyl ether (PBDE) mixture was a multispecies carcinogen causing liver tumors in male and female rats and mice.•Hras or Ctnnb1 mutations characterized the PBDE-induced liver tumors.•PBDE-induced liver tumors increased with increasing PBDE exposure.

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关键词

Pentabrominated diphenyl ethers,Liver toxicity,Carcinogenic activity

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