Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1.

Rama Krishna Nimmakayala,Parthasarathy Seshacharyulu,Imayavaramban Lakshmanan,Satyanarayana Rachagani,Seema Chugh,Saswati Karmakar,Sanchita Rauth,Raghupathy Vengoji,Pranita Atri,Geoffrey A Talmon,Subodh M Lele,Lynette M Smith,Ishwor Thapa,Dhundy Bastola,Michel M Ouellette,Surinder K Batra,Moorthy P Ponnusamy

Gastroenterology（2018）

引用 75|浏览27

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摘要

Exposure to cigarette smoke activates stem cell features of pancreatic cells, via CHRNA7 signaling and FOSL1 activation of PAF1 expression. Levels of PAF1 are increased in pancreatic tumors of humans and mice with chronic cigarette smoke exposure.

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关键词

PHF5A,ERK,Pancreatic Carcinogenesis,Nicotine Receptor Signaling

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