Functional cooperation between HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR

Shuyan Meng,Guorui Wang,Yang Lu,Zhen Fan

Lung Cancer（2018）

引用 22|浏览9

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摘要

•HIF-1α and c-Jun downregulation correlates with NSCLC cell response to gefitinib.•Gefitinib-resistant NSCLC cells exhibit high basal levels of HIF-1α and c-Jun.•Constitutively expressed HIF-1α upregulates c-Jun and makes NSCLC gefitinib resistant.•SEK1-JNK-c-Jun inhibition downregulates HIF-1α and sensitizes NSCLC to gefitinib.

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关键词

Non-small cell lung cancer,EGFR mutation,TKI,HIF-1α,c-Jun

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