The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells.

Nithila A Joseph,Shiow-Her Chiou,Zoe Lung,Cheng-Lin Yang,Tze-Yi Lin,Hui-Wen Chang,H Sunny Sun,Sachin Kumar Gupta,Laising Yen,Shulhn-Der Wang,Kuan-Chih Chow

Journal of hematology & oncology（2018）

引用 65|浏览15

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摘要

HGF/c-Met regulates expression of SAE2 and cirRNA CCDC66 to increase EMT and drug resistance of LADC cells. Multimodality drugs concurrently aiming at these targets would probably provide more benefits for cancer patients.

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关键词

CCDC66,EGFR,EMT,HGF,SAE2,SUMOylation,c-MET,cirRNA

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