A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects.

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2015）

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摘要

This first-in-man study of a compound-targeting QC inhibition justifies further development of PQ912 for the treatment of AD.

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关键词

Alzheimer's disease,Glutaminyl cyclase,QC inhibitor,Amyloid-beta,Pyroglutamate,pE-Aβ,Cerebrospinal fluid

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