The alteration of T790M between 19 del and L858R in NSCLC in the course of EGFR-TKIs therapy: a literature-based pooled analysis

Hengrui Liang
Hengrui Liang
Zhenkui Pan
Zhenkui Pan
Chengye Guo
Chengye Guo
Difei Chen
Difei Chen
Jianrong Zhang
Jianrong Zhang
Yiyin Zhang
Yiyin Zhang
Shiyan Tang
Shiyan Tang

Journal of thoracic disease, Volume 10, Issue 4, 2018, Pages 2311-2320.

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Keywords:
L858RNon-small cell lung cancer (NSCLC)T790Mepidermal growth factor receptor (EGFR)exon 19 deletions

Abstract:

Opposite to the situation of T790M, it was observed that T790M was more frequent in exon 19 deletion than in L858R among patients with acquired resistance to EGFR-TKIs. The difference in T790M alteration between 19 del and L858R encourages development of detection or treatment strategies for the specific resistance mechanism.

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