The alteration of T790M between 19 del and L858R in NSCLC in the course of EGFR-TKIs therapy: a literature-based pooled analysis

    Hengrui Liang
    Hengrui Liang
    Zhenkui Pan
    Zhenkui Pan
    Chengye Guo
    Chengye Guo
    Difei Chen
    Difei Chen
    Jianrong Zhang
    Jianrong Zhang
    Yiyin Zhang
    Yiyin Zhang
    Shiyan Tang
    Shiyan Tang

    Journal of thoracic disease, Volume 10, Issue 4, 2018, Pages 2311-2320.

    Cited by: 1|Bibtex|Views0|Links
    WOS
    Keywords:
    L858RNon-small cell lung cancer (NSCLC)T790Mepidermal growth factor receptor (EGFR)exon 19 deletions

    Abstract:

    Opposite to the situation of T790M, it was observed that T790M was more frequent in exon 19 deletion than in L858R among patients with acquired resistance to EGFR-TKIs. The difference in T790M alteration between 19 del and L858R encourages development of detection or treatment strategies for the specific resistance mechanism.

    Code:

    Data:

    Your rating :
    0

     

    Tags
    Comments