The alteration of T790M between 19 del and L858R in NSCLC in the course of EGFR-TKIs therapy: a literature-based pooled analysis
Journal of thoracic disease, Volume 10, Issue 4, 2018, Pages 2311-2320.
WOS
Keywords:
L858RNon-small cell lung cancer (NSCLC)T790Mepidermal growth factor receptor (EGFR)exon 19 deletions
Abstract:
Opposite to the situation of T790M, it was observed that T790M was more frequent in exon 19 deletion than in L858R among patients with acquired resistance to EGFR-TKIs. The difference in T790M alteration between 19 del and L858R encourages development of detection or treatment strategies for the specific resistance mechanism.
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