Endoplasmic reticulum stress in bipolar disorder? - BiP and CHOP gene expression- and XBP1 splicing analysis in peripheral blood.

Susanne A Bengesser,Eva Z Reininghaus,Nina Dalkner,Armin Birner, Helena Hohenberger,Robert Queissner,Frederike Fellendorf,Martina Platzer,Rene Pilz,Carlo Hamm,Alexandra Rieger,Hans-Peter Kapfhammer,Harald Mangge,Bernd Reininghaus,Nathalie Meier-Allard,Anika Stracke,Robert Fuchs,Sandra Holasek

Psychoneuroendocrinology（2018）

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摘要

•Gene expression of Unfolded Protein Response (e.g. BIP, CHOP, XBP1) was analysed in Bipolar Disorder and controls.•BiP gene expression was significantly higher in Bipolar Disorder.•Reduced total and unspliced XPB1 levels were detected in Bipolar Disorder.•XBP1 splicing itself was not altered in Bipolar Disorder.

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关键词

Bipolar Disorder,Endoplasmic Reticulum,ER stress,Unfolded Protein Response,BiP,GRP78,CHOP,XBP1

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