Prevalence and Clinicopathologic Significance of BRAF V600E Mutation in Chinese Multiple Myeloma Patients.

Coty H Y Cheung,Chi Keung Cheng,Kin-Mang Lau,Rosalina K L Ip,Nelson C N Chan,Tommy H C Tam,Raymond S M Wong,Radha Raghupathy,Natalie P H Chan,Margaret H L Ng

Clinical Lymphoma Myeloma and Leukemia（2018）

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摘要

Our study revealed a higher prevalence of BRAF V600E mutation in Chinese MM patients. The associated prognostic impacts on younger patients could be beneficial to risk stratification and potential application of BRAF-targeted therapies in Chinese MM management. This is the first large-scale study revealing the prevalence and clinicopathologic significances of BRAF V600E mutation in Chinese myeloma.

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Hypercalcemia,KRAS,NRAS,Prognosis,Survival

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