An in-depth analysis identifies two new independent signals in 11q23.3 associated with vitiligo in the Chinese Han population.
Journal of Dermatological Science(2017)
摘要
•Three SNPs (rs613791, rs523604, rs638893) showed significant association with vitiligo in the study in Han Chinese population.•Previously reported SNP rs638893 was replicated, two newly identified SNPs (rs613791 and rs523604) were all independent of the reported SNP rs638893, and they were also independent of each other.•SNP rs523604 and rs613791 are located in CXCR5, and CXCR5 is crucial for follicular helper T cells (Tfh), which plays a key role in the pathogenesis of autoimmune diseases.
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关键词
Vitiligo,Susceptibility gene,CXCR5,DDX6
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