BCL2 Regulates Differentiation of Intestinal Fibroblasts.

Bruce Weder,Céline Mamie,Gerhard Rogler,Stephen Clarke,Bradford McRae,Pedro A Ruiz,Martin Hausmann

GASTROENTEROLOGY（2018）

引用 16|浏览16

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摘要

BCL2 antagonist administration partially prevented fibrogenesis in both fibrosis models. The BCL2 antagonist reduced the expression of TGFβ-induced factors involved in differentiation of myofibroblasts, and therefore might represent a potential treatment option against CD-associated fibrosis.

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关键词

intestinal fibrosis, transplantation, myofibroblast differentiation, apoptosis, BCL2 antagonist ABT-737

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