Molecular Basis for the Loss-of-function Effects of the Alzheimer's Disease–associated R47H Variant of the Immune Receptor TREM2

Athena Sudom,Santosh Talreja,Jean Danao, Eric Bragg, Rob Kegel,Xiaoshan Min,Jason Richardson,Zhongqi Zhang,Nikolai Sharkov,Edoardo Marcora,Steve Thibault,Jodi Bradley,Steve Wood,Ai-Ching Lim,Hang Chen,Songli Wang,Ian N. Foltz,Shilpa Sambashivan,Zhulun Wang

JOURNAL OF BIOLOGICAL CHEMISTRY（2018）

Cited 88|Views34

Key words

Alzheimer disease,neuroinflammation,X-ray crystallography,lipid-binding protein,scavenger receptor,TREM2,R47H,neurodegeneration,microglia,antibody,myeloid cell,structure,triggering receptor expressed on myeloid cells 2

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined