MicroRNA-133a Impairs Perfusion Recovery after Hindlimb Ischemia in Diabetic Mice

    Lingdan Chen
    Lingdan Chen
    Tao Wang
    Tao Wang
    Li Zhao
    Li Zhao
    Wenli Chen
    Wenli Chen
    Mingjie Yuan
    Mingjie Yuan

    Bioscience reports, 2018.

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    Keywords:
    reactive oxygen speciesMicroRNA-133aangiogenesisnitric oxideperipheral arterial disease

    Abstract:

    Peripheral arterial disease (PAD) patients with diabetes mellitus suffer from impaired neovascularization after ischemia which results in poorer outcomes. MicroRNA (miR)-133a is excessively expressed in endothelial cells under diabetic conditions. Here, we test whether diabetes-induced miR-133a upregulation is involved in the impaired ca...More

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