Method selectivity evaluation using the co-feature ratio in LC/MS metabolomics: Comparison of HILIC stationary phase performance for the analysis of plasma, urine and cell extracts.

Albert Elmsjö,Jakob Haglöf,Mikael K R Engskog,Ida Erngren,Marika Nestor,Torbjörn Arvidsson,Curt Pettersson

Journal of Chromatography A（2018）

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摘要

•CFR estimates chromatographic and signal selectivity for a feature.•CFR were used for comparison of three HILIC columns.•Selectivity issues related primary to salt clusters, lipids and PEGs.•CFR can be used in combination with existing method development strategies.

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关键词

Hydrophilic interaction chromatography,Mass spectrometry,Metabolomics,Co-feature ratio (CFR),Salt clusters

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