Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios.

Jamie Toombs,Martha S Foiani,Henrietta Wellington,Ross W Paterson,Charles Arber,Amanda Heslegrave,Michael P Lunn,Jonathan M Schott,Selina Wray,Henrik Zetterberg

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring（2018）

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摘要

Use of Aβ ratios, in conjunction with concentrations, may mitigate confounding factors and assist the clinical diagnostic process for Alzheimer's disease.

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关键词

Alzheimer's disease,Amyloid β ratio,Preanalytical factors,Cerebrospinal fluid,Cell culture media,Surface adsorption

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