Comprehensive targeted super-deep next generation sequencing enhances differential diagnosis of solitary pulmonary nodules

Shiyong Li
Shiyong Li
Chunli Wang
Chunli Wang
Liping Liu
Liping Liu
Jilong Liu
Jilong Liu
Qiuhua Deng
Qiuhua Deng

Journal of thoracic disease, Volume 10, Issue Suppl 7, 2018.

Cited by: 1|Bibtex|Views19|Links
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Keywords:
Solid pulmonary nodulecirculating tumour DNA (ctDNA)early diagnosislung cancertumor mutational burden (TMB)

Abstract:

These results showed that lung cancer gene-targeted deep capture sequencing is not efficient enough to achieve ideal sensitivity by simply increasing the sequencing depth of ctDNA from early candidates. The sequencing could not be evaluated hotspot mutations in the early tumour stage. Nevertheless, a larger cohort is required to optimize ...More

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