Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex.

Garik V Mkrtchyan,Muammer Üçal,Andrea Müllebner,Sergiu Dumitrescu,Martina Kames,Rudolf Moldzio,Marek Molcanyi,Samuel Schaefer,Adelheid Weidinger,Ute Schaefer,Juergen Hescheler,Johanna Catharina Duvigneau,Heinz Redl,Victoria I Bunik,Andrey V Kozlov

Biochimica et Biophysica Acta (BBA) - Bioenergetics（2018）

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摘要

•Traumatic brain injury impairs mitochondrial respiration.•2-Oxoglutarate dehydrogenase is a major site of damage in mitochondria.•Inactivation of 2-oxoglutarate dehydrogenase is associated with neuroinflammation.•Thiamine protects 2-oxoglutarate dehydrogenase and mitochondrial respiration.

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关键词

ER,iNOS,OGDHC,PDH,TBI,ThDP,TNF

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