Differentiation of equine bone marrow derived mesenchymal stem cells increases the expression of immunogenic genes.

•Immunogenicity of differentiated equine mesenchymal stem cells (MSCs) was unknown.•Adipogenesis and osteogenesis, but not chondrogenesis, upregulated MHC-I in equine MSCs.•MHC-II expression increased after equine MSCs differentiation into the three lineages.•CD40 and CD80 expression was not induced in equine MSCs after differentiation.•MHC upregulation after differentiation might increase equine MSC immunogenicity.