Cells Stiffen for Cytokines.

In this issue of Cell Chemical Biology, Knoops et al. (2018) use a novel approach in immunology: combining confocal microscopy and atomic force microscopy to unravel the specific interaction of oxidized peroxiredoxin-5 with Toll-like receptor 4 that leads to the release of interleukin-1β and the stiffening of mammalian cells.