Effects of SC99 on cerebral ischemia-perfusion injury in rats: Selective modulation of microglia polarization to M2 phenotype via inhibiting JAK2-STAT3 pathway.

Yiping Ding,Jinhong Qian,Haiying Li,Haitao Shen,Xiang Li,Yan Kong,Zhuan Xu,Gang Chen

Neuroscience Research（2019）

引用 22|浏览5

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摘要

•JAK2/STAT3 pathway participates in brain I/R injury.•SC99 suppressed JAK2/STAT3 signaling in MCAO/R rats.•SC99 alleviated I/R-induced brain damage and played an anti-inflammatory action.•SC99 modulated microglia polarization to M2 phenotype selectively.

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关键词

AIS,CNS,DAPI,ELISA,ERK,FJB,HPLC,I/R,IL-1β,IL-10,IL-4,iNOS,JAK,MM,NF-κB,OGD/R,PKB,STAT3,SD rats,SOCS3,SchA,TUNEL,TNF-α

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