Arrhythmic Events In Brugada Syndrome: A Nationwide Israeli Survey Of The Clinical Characteristics, Treatment, And Long-Term Follow-Up (Israbru-Vf)
ISRAEL MEDICAL ASSOCIATION JOURNAL(2018)
摘要
Background: Limited information exists about detailed clinical characteristics and management of the small subset of Brugada syndrome (BrS) patients who had an arrhythmic event (AE).Objectives: To conduct the first nationwide survey focused on BrS patients with documented AE.Methods: Israeli electrophysiology units participated if they had treated BrS patients who had cardiac arrest (CA) (lethal/aborted; group 1) or experienced appropriate therapy for tachyarrhythmias after prophylactic implantable cardioverter defibrillator (ICD) implantation (group 2).Results: The cohort comprised 31 patients: 25 in group 1,6 in group 2. Group 1:96% male, mean CA age 38 years (range 1384). Nine patients (36%) presented with arrhythmic storm and three had a lethal outcome; 17 (68%) had spontaneous type 1 Brugada electrocardiography (ECG). An electrophysiology study (EPS) was performed on 11 patients with inducible ventricular fibrillation (VF) in 10, which was prevented by quinidine in 9/10 patients. During follow-up (143 +/- 119 months) eight patients experienced appropriate shocks, none while on quinidine. Group 2: all male, age 30-53 years; 4/6 patients had familial history of sudden death age: 50 years. Five patients had spontaneous type 1 Brugada ECG and four were asymptomatic at ICD implantation. EPS was performed in four patients with inducible VF in three. During long-term follow-up, five patients received 1 appropriate shocks, one had ATP for sustained VT (none taking quinidine). No AE recurred in patients subsequently treated with quinidine.Conclusions: CA from BrS is apparently a rare occurrence on a national scale and no AE occurred in any patient treated with quinidine.
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关键词
Brugada syndrome (BrS), cardiac arrest (CA), arrhythmic events (AE), quinidine, appropriate shocks
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