DCE-MRI in Human Gliomas: A Surrogate for Assessment of Invasive Hypoxia Marker HIF-1Α Based on MRI-Neuronavigation Stereotactic Biopsies.

Qian Xie,Juan Wu,Zunguo Du,Ningning Di,Ren Yan,Haopeng Pang,Teng Jin,Hua Zhang,Yue Wu,Yong Zhang,Zhenwei Yao,Xiaoyuan Feng

Academic Radiology（2019）

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摘要

Our study demonstrated HIF-1α to be a significant predictor of different grades of gliomas with high sensitivity and specificity. DCE-MRI is a useful, noninvasive imaging tool for quantitative evaluation of HIF-1α, and its parameters may be used as a surrogate for HIF-1α expression.

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关键词

Dynamic contrast-enhanced magnetic resonance imaging,hypoxia,hypoxia-inducible factor 1α,frameless stereotaxy,brain biopsy

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