Effect of free amino acids on bovine retinal pericytes.

S Vidhya, R Ramya, K Coral,K N Sulochana,S R Bharathidevi

Experimental Eye Research（2018）

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摘要

•Serine, glycine, alanine and phenylalanine along with branched chain amino acids increased in PDR vitreous.•These amino acids significantly down regulated VEGF and MMP 9 mRNA expression in retinal pericytes.•Hydroxyproline, glycine and lysine have a greater effect on pericytes towards differentiation to adipocytes.•Glycine other than being adipogenic was found to increase NRF2 and decrease UCP2 and TGF-β mRNA levels.

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关键词

TGF-ß,Adiponectin,PPARγ,PREF-1

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