Activation of coagulation and endothelium with concurrent impairment of anticoagulant mechanisms in patients with typhoid fever.

•Typhoid fever (TF) is a systemic illness and disseminated intravascular coagulation may occur.•This study includes 2 patients groups, blood culture-positive and PCR-positive patients.•The coagulation system is strongly activated in most TF patients involving all 3 major pathways.•A fifth of TF patients had marked thrombocytopenia, a proposed marker for severity of disease.