Benzo(a)pyrene promotes migration, invasion and metastasis of lung adenocarcinoma cells by upregulating TGIF.
Toxicology Letters(2018)
摘要
•BaP treatment increased the expression of TGIF mRNA and protein.•BaP treatment increased TGIF promoter-driven reporter gene expression.•BaP treatment promoted H157 cell migration, invasion and metastasis.•Silencing TGIF blocked BaP-induced H157 cell migration, invasion and metastasis.•TGIF overexpression was related to lung adenocarcinoma metastasis and smoke status.
更多查看译文
关键词
Benzo(a)pyrene,Lung adenocarcinoma,Migration,Invasion,Metastasis,TGIF
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络