Liraglutide attenuates the migration of retinal pericytes induced by advanced glycation end products.

Peptides(2018)

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摘要
•AGE-BSA induces the migration of primary retinal pericytes.•AGE-BSA changes the expressions of migration-related p-FAK/FAK, MMP-2 and vinculin.•PI3K/Akt pathway is implicated in AGE-BSA-induced retinal pericyte migration.•GLP-1 receptor is found to be expressed in retinal pericytes.•Liraglutide attenuates the migration by mediation of Glp1r and PI3K/Akt activation.
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关键词
AGEs,BRB,DR,ECM,FAK,FAs,GLP-1,Glp1r,MMP,p-FAK,PI3K
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