Extended Human Papillomavirus Genotype Distribution and Cervical Cytology Results in a Large Cohort of Chinese Women With Invasive Cervical Cancers and High-Grade Squamous Intraepithelial Lesions.

Objectives: To study the human papillomavirus (HPV) genotype distribution of cervical cancer (CxCa) and cervical intraepithelial neoplasia grade 2/3 (CIN2/3). Methods: Patients with CxCa and CIN 2/3 diagnoses and HPV genotype testing in the prior 6 months were documented. Available prior Papanicolaou (Pap) results were also recorded. Results: Three hundred and seventy CxCa cases and 2,774 CIN 2/3 cases with recent prior HPV test results were documented. The high-risk (hr) HPV-positive rate was 88.4% for CxCa and 90.1% for CIN 2/3. Among 327 HPV-positive CxCa cases, the most common HPV types were HPV 16 (70.3%), 18 (7.0%), 58 (5.7%), and 33 (4.1%). Among 2,499 hrHPV-positive CIN 2/3 cases, the most common HPV types were HPV 16 (53.3%), 58 (21.4%), 52 (11%), 33 (10.6%) and 18 (5.1%). For the cotested cases hrHPV-negative results were reported in 12.4% of CxCa and 10.1% of CIN 2/3 cases compared to cytology-negative results reported in 15.5% of CxCa and 4.3% of CIN 2/3. Conclusions: HPV 16/18/59/39 genotypes were significantly more prevalent in CxCa cases than in CIN 2/3 cases, consistent with the more limited progressive potential of some CIN 2/3 lesions. 10% to 12% of CIN 2/3 and CxCa cases had recent negative hrHPV test results, pointing to the limitation of primary HPV screening.