A new probe for detecting zinc-bound carbonic anhydrase in cell lysates and cells.

Radhika Mehta, Munaum H Qureshi, Meredith K Purchal,Sylvester M Greer,Shanzhong Gong,Chinh Ngo,Emily L Que

CHEMICAL COMMUNICATIONS（2018）

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摘要

We report the synthesis and application of a small molecule probe for carbonic anhydrase (CA) to track holo-CA in cell lysates and live-cell models of zinc dyshomeostasis. The probe displays a 12-fold increase in fluorescence upon binding to bovine CA and also responds to human CA isoforms.

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关键词

carbonic anhydrase,cell lysates,cells,zinc-bound

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