Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- A]pyridin-3-yl)methane-sulfonamides As Potent and Selective Hnav1.7 Inhibitors for the Treatment of Pain. Thilo Focken , Sultan Chowdhury , Alla Zenova , Michael E. Grimwood , Christine Chabot , Tao Sheng , Ivan Hemeon , Shannon M. Decker , Michael Wilson , Paul Bichler , Qi Jia , Shaoyi Sun , Clint Young , Sophia Lin , Samuel J. Goodchild , Noah G. Shuart , Elaine Chang , Zhiwei Xie , Bowen Li , Kuldip Khakh , Girish Bankar , Matthew Waldbrook , Rainbow Kwan , Karen Nelkenbrecher , Parisa Karimi Tari , Navjot Chahal , Luis Sojo , C. Lee Robinette , Andrew D. White , Chien-An Chen , Yi Zhang , Jodie Pang , Jae H. Chang , David H. Hackos , J. P. Johnson , Charles J. Cohen , Daniel F. Ortwine , Daniel P. Sutherlin , Christoph M. Dehnhardt , Brian S. Safina Journal of Medicinal Chemistry（2018）
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