Abnormal Trajectory of Intracortical Myelination in Schizophrenia Implicates White Matter in Disease Pathophysiology and the Therapeutic Mechanism of Action of Antipsychotics

Todd A Tishler
Todd A Tishler
Mher Khanoyan
Mher Khanoyan
Chandra J Kirkpatrick
Chandra J Kirkpatrick
Meghan H Pyle
Meghan H Pyle
Laurie R Casaus
Laurie R Casaus

Biological psychiatry. Cognitive neuroscience and neuroimaging, Volume 3, Issue 5, 2018, Pages 454-462.

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Keywords:
Atypical antipsychoticMedicationMyelinOligodendrocyteSchizophreniaMore(1+)

Abstract:

In adults with SZ, the relationship between length of exposure to oral second-generation antipsychotics and ICM was positive during the first year of treatment but was negative after this initial period, consistent with suboptimal later adherence after initial adherence. This ICM trajectory resembles clinically observed antipsychotic resp...More

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