Role of methionine 71 in substrate recognition and structural integrity of bacterial peptidyl-tRNA hydrolase.

Salman Shahid,Ashish Kabra,Surbhi Mundra,Ravi Kant Pal,Sarita Tripathi,Anupam Jain,Ashish Arora

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics（2018）

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摘要

•Peptidyl-tRNA hydrolase selectively hydrolyzes only N-blocked aminoacyl-tRNAs.•The active site residues of Pth are N14, H24, N72, D97 and N118.•Residue M71 is highly conserved and has important interactions with N14 and H24.•The structure, dynamics and stability of M71A were characterized.•M71 is important for the activity, stability, and compactness of the protein.

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关键词

Pth,RRF,HSQC,CSP,DSC,MD,RMSF,RMSD

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