Neuroinflammation markers and methyl alcohol induced toxic brain damage.

Sergey Zakharov,Jiri Hlusicka,Olga Nurieva,Katerina Kotikova,Lucie Lischkova,Petr Kacer,Tereza Kacerova,Pavel Urban,Manuela Vaneckova,Zdenek Seidl,Pavel Diblik,Pavel Kuthan,Jarmila Heissigerova, Jiri Lesovsky,Jan Rulisek,Lucie Vojtova,Jaroslav A Hubacek,Tomas Navratil

Toxicology Letters（2018）

引用 12|浏览55

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摘要

•Acute methyl alcohol intoxication leads to an inflammatory response in the brain.•Acute concentrations of IL-4, IL-5, IL-9, IL-10, IL-13, LxA4 and LxB4 were elevated.•The acute elevation did not persist suggesting against chronic neuroinflammation.•Association of the follow-up IL-5 concentration with abnormal optic nerve function.•Association of the follow-up IL-10 concentration with brain necrotic lesions.

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关键词

Neuroinflammation,Methyl alcohol poisoning,CNS damage,Interleukins,Lipoxins,Non-traumatic brain injury

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