Efficient computation of co-transcriptional RNA-ligand interaction dynamics.

Michael T Wolfinger,Christoph Flamm,Ivo L Hofacker

Methods（2018）

引用 11|浏览29

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摘要

•Co-transcriptional RNA-ligand interaction dynamics are simulated for riboswitches under kinetic control.•Ligand concentration and binding energy effects are modeled efficiently.•Our framework can be used in riboswitch design for synthetic biology applications.

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关键词

RNA-ligand interaction,RNA dynamics,Co-transcriptional folding,Energy landscape,Riboswitch

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