Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy.

Kathleen Lee-Sarwar,Rachel S Kelly,Jessica Lasky-Su,D Branch Moody,Alex R Mola,Tan-Yun Cheng,Laurie E Comstock,Robert S Zeiger,George T O'Connor,Megan T Sandel,Leonard B Bacharier,Avraham Beigelman,Nancy Laranjo,Diane R Gold,Supinda Bunyavanich,Jessica H Savage,Scott T Weiss,Patrick J Brennan,Augusto A Litonjua

The Journal of allergy and clinical immunology（2018）

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摘要

Intestinal Bacteroides-derived sphingolipids in infancy were inversely associated with food allergy among sensitized subjects. This may be mediated in part by invariant NK T cell activation.

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