Methacholine induces extracellular matrix production by human airway smooth muscle cells through β-catenin signaling.

Yating Huo,Jiawen Xu,Lili Guan,Weiliang Wu,Bingpeng Guo,Yuqiong Yang,Lin Lin,Yonger Ou,Fangfang Jiang,Luqian Zhou, Rongchang Chen

Respiratory Physiology & Neurobiology（2018）

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摘要

•Methacholine increases ECM production by human ASMCs.•β-Catenin signaling is required for methacholine-induced ECM production.•Methacholine induces ECM production partially through TGF-β.

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关键词

Methacholine,Collagen I,β-catenin,GSK3β,TGF-β,Human airway smooth muscle cells

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