HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia

•HLA-G molecules play a role in cancer immune-editing and NK cell inhibition.•Lower event free survival in CML is associated to higher level of HLA-G.•Deeper molecular response in CML is associated to lower level of HLA-G.•HLA-G could represent a new useful predictive immune biomarker in CML.•HLA-G is an innovative target for immune-mediated treatment approaches.