Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Brian Y H Lam,Irene Cimino,Joseph Polex-Wolf,Sara Nicole Kohnke,Debra Rimmington,Valentine Iyemere,Nicholas Heeley,Chiara Cossetti,Reiner Schulte,Luis R Saraiva,Darren W Logan,Clemence Blouet,Stephen O'Rahilly,Anthony P Coll,Giles S H Yeo

Molecular Metabolism（2017）

引用 126|浏览25

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摘要

•Hypothalamic POMC neurons are heterogeneous and can broadly divided into 4 groups.•Cell surface receptors are major drivers for the segregation.•Unexpectedly, 28% of POMC-cells show signatures typical of AgRP/NPY neurons.•Only 12% express leptin receptor, indicating response to leptin is likely indirect.

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关键词

POMC,Melanocortin,AGRP,Leptin,Insulin,Hypothalamus,Arcuate nucleus,Gene expression,Neuron,Transcriptome

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