HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs.
Journal of Hepatology(2017)
摘要
After exposure to HCV, the majority of PWID develop chronic HCV infection that can lead to liver cirrhosis and hepatocellular carcinoma. A small subgroup of PWID is able to clear HCV infection before and after seroconversion. PWID with multiple Bw4 alleles are more likely to clear HCV prior to seroconversion than PWID with one or no Bw4 allele. In addition, PWID that encode both KIR3DL1 and a Bw4 80(T) motif have higher chances of spontaneously clearing HCV after seroconversion.
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关键词
Killer cell immunoglobulin-like receptor,KIR3DL1,Hepatitis C,HCV,NK cell
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