Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice.

•A novel resveratrol-based topical cream alleviates acute postoperative pain and hyperalgesic priming.•Combination treatments of resveratrol and metformin have additive effects on acute sensitivity and hyperalgesic priming.•AMPK activators do not negatively influence wound healing.