Matrix protein Tenascin C expands and reversibly blocks maturation of murine eosinophil progenitors.

Ton C Doan,Brian M Jeong,Mackenzie E Coden,Lucas F Loffredo,Swati Bhattacharyya,Sergio E Chiarella,John Varga,Hiam Abdala-Valencia,Sergejs Berdnikovs

Journal of Allergy and Clinical Immunology（2018）

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摘要

We show that Tenascin-C, an asthma-associated extracellular matrix glycoprotein, promotes hematopoietic progenitors and suppresses the IL-5-driven maturation of murine lung eosinophils. The extracellular matrix's regulation of in situ hematopoiesis has significant implications for targeting tissue eosinophils.

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关键词

Extracellular matrix,Tenascin-C,allergy,asthma,bone marrow,eosinophils,hematopoietic stem cells,in situ hematopoiesis,lung tissue

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