Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia.

Mariana I Holubiec,Juan I Romero,Eduardo Blanco, Tamara Logica Tornatore,Juan Suarez,Fernando Rodríguez de Fonseca,Pablo Galeano,Francisco Capani

Neuroscience Letters（2017）

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摘要

•Perinatal asphyxia results in astrogliosis in the dorsal striatum.•Perinatal asphyxia induces a decrease in the expression of NAPE-PLD in dorsal striatum.•Perinatal asphyxia decreases the expression of PPARα receptor in dorsal striatum.•Acylethanolamides and the endocannabinoid system play a key role in perinatal asphyxia.

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关键词

2-AG,AEA,AEs,CB1,CB2,DAGL,eCBs,ECS,FAAH,MAGL,MAGs,NAPE,NAPE‐PLD,OEA,PA,PEA,PPARα

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