Genetic deletion of GPR52 enhances the locomotor-stimulating effect of an adenosine A 2A receptor antagonist in mice: A potential role of GPR52 in the function of striatopallidal neurons.

Keiji Nishiyama,Hirobumi Suzuki,Minoru Maruyama,Tomoki Yoshihara,Hiroyuki Ohta

Brain Research（2017）

引用 13|浏览19

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摘要

•GPR52 KO mice were hypersensitive to an adenosine A2A receptor antagonist.•GPR52 KO mice had reduced striatal expression of enkephalin mRNA.•GPR52 may be involved in modulating the function of striatopallidal neurons.

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关键词

ADORA2A,DRD1,DRD2,GPCR,KO,NMDA,mAb,qPCR,WT

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