IL-17 deficiency attenuates acetaminophen-induced hepatotoxicity in mice.

Hung-Chen Lee,Chia-Chih Liao,Yuan-Ji Day,Jiin-Tarng Liou,Allen H Li,Fu-Chao Liu

Toxicology Letters（2018）

引用 20|浏览8

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摘要

•IL-17 deficiency markedly attenuates APAP-induced liver injury.•IL-17 deficiency attenuates the ERK phosphorylation during APAP-induced liver injury.•Blockade of IL-17 may be a potential therapeutic target for APAP-induced liver injury.

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关键词

IL-17,Acetaminophen,Hepatotoxicity,ERK

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