Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.

Melissa H Bloodworth,Mark Rusznak, Connor C Pfister,Jian Zhang,Lisa Bastarache, Sandra Alvarez Calvillo,James D Chappell,Kelli L Boyd,Shinji Toki,Dawn C Newcomb,Matthew T Stier,Weisong Zhou,Kasia Goleniewska,Martin L Moore,Tina V Hartert,Kevin D Niswender,R Stokes Peebles

The Journal of allergy and clinical immunology（2018）

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摘要

GLP-1R signaling, an emerging anti-inflammatory therapeutic target, attenuated type 2-associated immunopathology in mice infected with a strain of RSV that was isolated from a hospitalized infant with severe lower respiratory tract infection and bronchiolitis.

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