GPR68 Senses Flow and Is Essential for Vascular Physiology

Scott Hammack
Scott Hammack
Keiko Nonomura
Keiko Nonomura
Julie Favre
Julie Favre
Allain Francisco
Allain Francisco
Jingyuan Li
Jingyuan Li
Van Lee
Van Lee
Fu-Li Xiang
Fu-Li Xiang

Cell, Volume 173, Issue 3, 2018, Pages 762

Cited by: 6|Bibtex|Views49|Links
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Keywords:
GPCRblood flowmechanosensationmechanotransductionoutward remodelingMore(3+)

Abstract:

Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark of endothelial dysfunction and a precursor to a wide array of vascular diseases, such as hypertension and atherosclerosis. Yet the molec...More

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