Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells.

Girolamo Spagnoletti,Valeria Li Bergolis,Annamaria Piscazzi, Francesca Giannelli,Valentina Condelli,Lorenza Sisinni, Giuseppe Bove,Giovanni Storto,Matteo Landriscina

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine（2018）

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摘要

These data suggest that BRAF V600E colorectal carcinoma cells are poorly responsive to radiation, and cyclin-dependent kinase 1 represents a target to improve radiosensitivity in BRAF V600E colorectal tumor cells.

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关键词

BRAF,CDK1,HSP990,radioresistance,radiotherapy

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