Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2) displays an unexpected subcellular localization in the plasma membrane.

Maxime Delos,François Foulquier,Charles Hellec,Dorothée Vicogne,Alexandre Fifre,Mathieu Carpentier,Dulce Papy-Garcia,Fabrice Allain,Agnès Denys

Biochimica et Biophysica Acta (BBA) - General Subjects（2018）

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摘要

•Heparan sulfate 3-O-sulfotransferase 3B (HS3ST3B) is a Golgi-resident enzyme.•Unlike HS3ST3B, HS3ST2 is expressed in the vicinity of the plasma membrane.•HS3ST2 co-localizes with the proteoglycan syndecan-2 in the plasma membrane.•Syndecan-2 is required to address HS3ST2 outside of the Golgi apparatus.

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关键词

BSA,ER,EXTL3,FCS,GlcN,GlcNS,GlcUA,HPRT,HS,HS2ST, HS3ST, HS6ST,HSV-1,IdoUA,NDST,PBS,RFP,siRNA,TBS,WT

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