The CB1 antagonist, SR141716A, is protective in permanent photothrombotic cerebral ischemia.

Zachary Wilmer Reichenbach,Hongbo Li,Sara Jane Ward,Ronald F Tuma

Neuroscience Letters（2016）

引用 9|浏览5

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摘要

•The CB1 antagonist, SR141716A is protective in photochemically induced ischemia.•The CB1 antagonist, SR141716A, results in reduced size of infarctions.•The CB1 antagonist, SR141716A, does not rely on 5HT1AR for its protective effect.•The SR141716A improves neurological function after stroke when given prior to injury.

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关键词

Stroke,Cerebral ischemia,CB1 antagonist,Cannabinoid receptor,Photochemical injury,Permanent occlusion

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