Novel role of GLP-1 receptor signaling in energy expenditure during chronic high fat diet feeding in rats.

•Chronic IP Ex9 reduces weight gain in high fat diet (HFD)-, but not chow-fed rats.•Chronic Ex9 does not affect eating, but enhances energy expenditure in HFD-fed rats.•Chronic Ex9 worsens glucose tolerance in chow-fed, but not in HFD-fed rats.