LncRNA ASAP1-IT1 positively modulates the development of cholangiocarcinoma via hedgehog signaling pathway.

Biomedicine & Pharmacotherapy(2018)

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摘要
•ASAP1-IT1 is upregulated in CCA tissues and cells.•Knockdown of ASAP1-IT1 impedes cell proliferation, cell migration and EMT progress in CCA.•ASAP1-IT1 activates hedgehog pathway through upregulating Smo and Gli1.•ASAP1-IT1 improves CCA progression through activating hedgehog signaling pathway.
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关键词
CCA,ASAP1-IT1,Proliferation,Migration,Hedgehog signaling pathway
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